The Numerous Caveats of Designing, Implementing, and Interpreting Genome-Wide Association Studies
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چکیده
The information to be made available by genome-wide association (GWA) studies has long been heralded as the future of healthcare and personalized medicine. It has been suggested that knowledge linking particular DNA sequences to diseases will provide a strong foundation for preventative medicine. GWA studies have already proven successful in predicting loci associated with age-related macular degeneration, myocardial infarction, and type 2 diabetes [1]. In fact, more than 250 genetic loci that contribute to phenotypes observed as diseases or other quantitative traits (traits determined by the effect of a number of different loci), such as height, have been identified [2].
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تاریخ انتشار 2010